Definition, history, classification of biotechnology; basic knowledge of industrial microbiology; fermentation technology; bioprocess engineering; reactor design, scale up, process optimization; advanced microbial physiology, metabolisms and regulations; related process, techniques, product and innovation in biotechnology; various applications of biotechnology including food, energy, environment, agriculture as well as medical field; economics, patent, laws and business relating to biotechnology, ethics in biotechnology; recent research in biotechnology; case study.